Metatrol Pro* Fermented Wheat Germ Extract 

Metatrol PRO® stands as the ultimate Fermented Wheat Germ Extract (FWGE) on the market.

American BioSciences researchers deployed the most advanced and sophisticated isolation techniques to identify the active molecules in fermented wheat germ. Subsequently, they developed an unparalleled manufacturing technique that extracts those specific active molecules, resulting in fermented wheat germ extract – super concentrate (FWGE-SC).

It has been confirmed by studies that Metatrol PRO® contains 41 mg of FWGE-SC which has the same biological activity as one packet of AvéULTRA®.

This means that Metatrol PRO® can offer essential health benefits to your patients such as:*

• Regulating cell metabolism.
• It helps to rescue mitochondrial function. 
• Enhancing mechanisms of cellular repair and differentiation. 
• Regulating immune system support and the balance of Th1 and Th2.

Plus, Metatrol PRO® has these added benefits:*

• This is a super-concentrated fermented wheat germ extract. Just two capsules have the same biological effect as one packet of AvéULTRA®. 
• It is more convenient to take. No mixing is necessary. 
• It's gluten-free, so those with gluten allergies can enjoy it without worry. 
• It's stable at higher temperatures. No refrigeration is needed! 

Suggested Use:

As a dietary supplement for adults, take 2 Metatrol PRO® capsules daily (before, during or after meals, as preferred). For people weighing over 200 lbs, take 4 Metatrol PRO capsules daily. 

60 Caps

For animals:  Please get in touch with me. 

More about Avemar: Fermented Wheat Germ Extract (FWGE)

Fermented Wheat Germ Extract (FWGE), also commercially known as Avemar, originates from the industrial fermentation of wheat germ. The production process of FWGE is patented. The extraction from wheat germ undergoes fermentation by Saccharomyces cerevisiae, which is then followed by the separation of the fermentation liquid. 

The resulting substance undergoes drying and granulation. In the context of molecular content, FWGE is believed to contain various molecules. Of particular interest are two quinones, 2-methoxy benzoquinone and 2, 6-dimethoxy benzoquinone, which are naturally present in wheat germ as glucosides. These quinones are believed to be responsible for some of the biological properties of FWGE[[2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213720/)].

Application and Potential Benefits in Cancer:

Adjunct Therapy 

Research has examined the effectiveness of FWGE as an adjunct therapy in the treatment of cancer, both haematological and non-haematological. An adjunct therapy means it is used in combination with conventional treatments such as surgery, chemotherapy, radiotherapy, and hormone therapies[[1](https://pubmed.ncbi.nlm.nih.gov/27820157/)].

In Vitro Effects 

A systematic review focused on the in vitro activity of FWGE on malignant cells. Findings from various studies showed that FWGE has cytotoxic effects on different types of cancer cells. It can alter the cell cycle, has antiproliferative effects, and can induce apoptosis (programmed cell death) in cancer cells[[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213720/

Historical Interest: 

International attention regarding FWGE's potential as a cancer treatment has been growing since the early 1990s. Dr. Albert Szent-Gyorgyi noted that the fermented wheat germ product had positive effects in preventing cancer cell growth. Decades later, these properties were further researched and implemented as a potential therapy for cancer patients.
https://pubmed.ncbi.nlm.nih.gov/27820157/

Anticancer Mechanisms: 

Some anticancer compounds are quinone derivatives, and the anticancer properties of AVEMAR (FWGE) have been explored in depth. The results have indicated its metabolic, antiproliferative, and antimetastatic effects. Specifically, the antimetabolic effects of FWGE on cancer cells seem to arise due to the hypermetabolic state of these cells and their increased use of glucose. Its antimetastatic effect might also be attributed to its immune-reconstituting properties https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213720/

Other Potential Benefits:*

Apart from cancer, FWGE has been studied for its protective effects against inflammation and oxidative stress. In one study, FWGE demonstrated significant anti-inflammatory effects, especially related to oxidative stress, in IPEC-J2 porcine intestinal epithelial cells exposed to LPS (a component from the outer membrane of Gram-negative bacteria that can induce inflammation).

Treatment with FWGE (1-2%) notably decreased the level of intracellular reactive oxygen species (ROS) in comparison to cells treated with LPS alone. Moreover, the disruption of epithelial integrity, which was triggered by LPS, was reduced after applying FWGE. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436289/

In Conclusion

Fermented Wheat Germ Extract (FWGE), particularly its commercial variant Avemar, has gained attention in the scientific community for its potential anticancer properties and benefits against inflammation and oxidative stress. While preliminary studies offer promising results, further in-depth studies, both in vitro and in vivo, are necessary to validate its effectiveness and safety for human use.

*This product has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.