Prostabel® is a unique and proprietary formula that promotes the health of cells.*

Prostabel is a combination Pao Pereira and Rauwolfia Vomitoria

Ingredients: Herbal Proprietary Blend (Pao pereira (Geissospermum vellosii) extract (bark), Rauwolfia (Rauwolfia vomitoria) extract (root bark, reserpine and yohimbine free), Microcrystalline Cellulose 102, Gum Arabic, Tapioca Dextrin, Organic Rice Concentrate (Nu-flow®)

Rauwolfia vomitoria

Is a dietary supplement based on a purified extract (without reserpine) from the root of Rauwolfia vomitoria. It exerts a protective role, promoting the healthy regulation of cells.

In healthy, well-regulated cells, the DNA chains open and close according to the need for duplication and transcription. Our world is filled with aggressive and toxic compounds as well as hormones capable of causing a disruption of cells by causing unregulated opening of the DNA which can have a detrimental effect on the proper functioning of the whole organism.¹

Pao pereira

Even though they lived in a naturally preserved environment for centuries, South American Indian tribes used Pao pereira bark (Geissospermum vellosii), a tree from the Amazonian rain forest, particularly when additional support for the immune system was needed.¹*

Our immune system constantly destroys and cleanses imperfect cells as they appear in our bodies. In our modern environment, our tissues are increasingly exposed to new aggressive pollutants that push our internal purification capacities to their limits.^2,3

By opposing the interference of these pollutants, Pao pereira (formerly known as PB-100) helps support the body’s own immune and detoxification systems to eliminate or neutralize undesirable cells.⁴*

Contents: 100 vegetarian capsules per bottle. Each capsule contains a proprietary blend of powdered Pao pereira extract and powdered Rauwolfia vomitoria extract.

Suggested dose: Ask me for dosages. In most cases 2 per day is normal. 

Caution: Avoid taking silica at the same time as Pao pereria

This product is Reserpine and Yohimbine free

Our formulation does not contain any known allergens. However, while our Manufacturers take steps to minimize the risk of any cross contact, we cannot guarantee that any of our products do not contain trace amounts of, and are safe for consumers with peanut, tree nut, soy, milk, egg, shellfish or wheat allergies.

More about Rauwolfia Vomitoria, including studies

Rauvolfia vomitoria, also known as poison devil's-pepper, is a plant species belonging to the genus Rauvolfia and the family Apocynaceae. It is native to various regions in Africa, including Senegal, Sudan, Tanzania, and Angola, and has been naturalized in China, Bangladesh, parts of the Himalayas, and Puerto Rico [1][2]. This plant is a small tree or large shrub that can grow up to 8 meters (26 feet) in height. Its branches grow in whorls, and the leaves grow in groups of three from swollen nodes. The leaf blades are broadly lanceolate or elliptical, tapering to a long point. Fragrant flowers are followed by globular red fruit. All parts of the plant, except the mature wood, contain latex [1][2].

In terms of ecology, Rauvolfia vomitoria is a fast-growing tree that produces a large quantity of seeds dispersed by birds. The seedlings and saplings are tolerant of shade, and the tree can regenerate after cutting or burning, quickly forming dense thickets [2].

Rauvolfia vomitoria has been used in traditional medicine across its range. The roots of the plant are commonly decocted or extracted and used for various purposes such as treating:

• diarrhea
• jaundice
• venereal diseases
• rheumatism
• snakebites
• colic
• fever
• anxiety
• epilepsy
• lowering blood pressure

Additionally, the macerated root or pulped fruit is used for various skin conditions. The plant contains several compounds of interest to the pharmaceutical industry [1][2].

It is important to note that Rauvolfia vomitoria has been identified as an invasive species on the Hawaiian island of Oahu [1].

Regarding its uses and effectiveness, Rauvolfia vomitoria has been used for different purposes, such as athletic performance, diabetes, psychosis, fever, cancer, and high blood pressure. However, there is currently no good scientific evidence to support these uses, and the plant might have safety concerns. Some countries have even banned supplements containing Rauvolfia vomitoria extract from the market due to the high levels of chemicals that are prescription drugs [3].

To summarize, Rauvolfia vomitoria is a plant species with a wide distribution in Africa and other regions. It has a history of traditional medicinal uses and contains compounds of pharmaceutical interest. However, further research is needed to validate its potential benefits and ensure safe usage.

References:

1. Wikipedia. Rauvolfia vomitoria. Retrieved from [1] and [2]. Link: https://en.wikipedia.org/wiki/Rauvolfia_vomitoria
2. WebMD. Rauvolfia vomitoria - Uses, Side Effects, and More. Retrieved from [3]. Link : https://www.webmd.com/vitamins/ai/ingredientmono-1546/rauvolfia-vomitoria
3. National Tropical Botanical Garden. Rauvolfia vomitoria. Retrieved from [4]. Link: https://ntbg.org/database/plants/detail/rauvolfia-vomitoria

More about Pao Pereire, including studies 

Pao Pereira, often referred to as "Pao," is an extract derived from the bark of an Amazonian tree. Its potential benefits have been studied in the context of several diseases, including cancer and benign prostatic hyperplasia (BPH).

Studies show that Pao Pereira may have significant effects in the treatment of pancreatic cancer, particularly in relation to cancer stem-like cells (CSCs) which are known to be resistant to conventional chemotherapies and responsible for tumor metastasis and recurrence. The extract is noted to have inhibited the overall proliferation of human pancreatic cancer cell lines with IC50 ranging from 125 to 325 μg/mL and showed limited cytotoxicity to normal epithelial cells.

The population of pancreatic CSCs, identified using surface markers or tumor spheroid formation assay, was significantly reduced with IC50s of ~100 μg/mL for 48 hours treatment, and ~27 μg/mL for long-term treatment. The extract also appeared to decrease nuclear β-catenin levels, suggesting suppression of the Wnt/β-catenin signaling pathway, a key pathway involved in cancer development. In in vivo experiments, Pao at 20 mg/kg, 5 times/week gavage, significantly reduced tumorigenicity of PANC-1 cells in immunocompromised mice, indicating inhibition of CSCs in vivo [[1] (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247539/)] .

Pao Pereira has also been studied in the context of BPH, a non-malignant enlargement of the prostate gland that is common in older males. The extract was found to inhibit viability and induce apoptosis in human BPH epithelial BPH-1 and prostate myofibroblast WPMY-1 cells. Gene expression profiling indicated that the expression levels of pro-apoptotic genes (PCDC4, CHOP and FBXO32) were induced by Pao extract. Further, it was found that Pao extract treatment was negatively associated with the activation of NFκB signaling, a key regulator of inflammation. It was able to suppress the transcriptional activity of NFκB and down-regulate its target genes involved in inflammation (CXCL5, CXCL6 and CXCL12) and extracellular matrix (ECM) remodeling (HAS2, TNC and MMP13) in both cultured cells and human ex vivo BPH explants [[2](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231430/), [3](https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-020-02943-2 )]

Overall, these studies suggest that Pao Pereira has potential therapeutic effects against pancreatic cancer and benign prostatic hyperplasia. However, it is important to note that more research and clinical trials are needed to fully understand the safety and efficacy of Pao Pereira for these conditions. It is also crucial to consult with healthcare providers before starting any new treatments.

¹ M. BELJANSKI, "The Regulation of DNA Replication and Transcription. The Role of Trigger Molecules in Normal and Malignant Gene Expression". EVI Liberty (2003), (First Edition: Experimental Biology and Medicine, vol.8, Karger-1983), pp. 11-15.

² JEAN BERHAUT ”Flore illustrée du Sénégal”, Dakar, 1971, pp 420-421

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.